About 30% cellular proteins are protein kinases. Only a tiny of our genes is transcripted for RNA in the cellular process in order to produce proteins. The most of double strand DNA sequences are tightly packed without being accessed to proteins responsible for DNA duplication. For example, DNA helicases, DNA polymerases, single strand DNA binding proteins for stable the single DNA molecules, and other gene regulated proteins or factors. The major function of protein kinases is to phosphating of the hydroxy group of amino acid residues (serine, threonine, and tyrosine) of double strand DNA packing proteins which will results in opened up highly compacted double strand DNA molecules and become accessible for their duplication, which lead to overexpress of genes or 5′-hydroxy group of nucleic acid. We offered a varies of protein kinase inhibitors for your research purposes.